Combination of Probiotics May Slow Fat Buildup in Liver and Adipose Tissue: Study

Data published in Beneficial microbes indicated that the combination of Limosilactobacillus fermentum *MG4231, MG4244 decreased weight gain in laboratory mice consuming a high fat (Western) diet by nearly 30%.

The strain combination has also been linked to improvements in total and LDL cholesterol levels in laboratory animals, scientists from Duksung Women’s University, Inje University and Mediogen Co., Ltd. reported. in South Korea.

“We found that administration of the combination of MG4231 and MG4244 in obese HFD-fed C57BL / 6J mice further reduced weight gain, fat accumulation, inflammation, and adipocyte expansion in the body. liver and adipose tissue in relation to individual administration of the strains’ they wrote.

“Therefore, the combination of L. ferment MG4231 and MG4244 may be a potential probiotic candidate for the prevention of obesity.

* L. fermentumwas formerly known as Lactobacillus fermentum. For more information on taxonomic changes in the genus Lactobacilli,please click HERE.


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The link between the gut microbiota and obesity was first reported by Jeffrey Gordon and his group at Washington University in St. Louis, who found that microbial populations in the gut were different between people. obese and lean people, and when obese people lost weight, their microflora returned to that seen in a lean person. This suggests that obesity has a microbial component (Nature, Flight. 444, pages 1022-1023, 1027-1031).

A 2013 article in Science(Vol. 341, Number 6150), also led by Professor Gordon, found that transplantation of gut bacteria from obese humans into germ-free mice resulted in greater weight gain and fat accumulation than mice. having received bacteria from the intestines of lean humans. .

This has led many research groups to explore whether probiotics can help with weight management. A probiotic is defined as a “Living micro-organisms which, when administered in adequate amounts, confer a health benefit on the host”– FAO / WHO.

Study details

The new study divided the male lab mice into five groups: a control group ate a normal diet; another control group consumed a high fat diet (HFD); the other three groups consumed HFD with L. fermentumMG4231 only, L. closeMG4244 alone, or a combination of MG4231 and MG4244. The probiotic was used in daily doses of 200 million CFU per mouse.

After eight weeks of intervention, data indicated that, as expected, consuming a high-fat diet resulted in significant weight gain, with the HFD-only group (group 2) gaining 19.6 grams, compared with just 5. , 2 grams in the group with a normal diet. Mice given the MG4244 strain and the combination of strains still gained weight, but significantly less than the high-fat-only group: the MG4244 group gained an average of 16.3 g, while the combination group took on average 14.2 g.

Additionally, liver weight increased in the high fat group (group 2), but it was “significantly lower” in the strain combination group, the researchers said. Epididymal adipose tissue (white fat) and subcutaneous adipose tissue increased 8-fold and 13-fold, respectively, in the HFD group compared to mice fed a normal diet.

“On the other hand, these tissue weights were significantly reduced in all groups treated with L. fermentum. In particular, in the group treated by combination, the weight of epididymal and subcutaneous tissue was reduced by 22% and 58%, respectively ”, the researchers reported.

Probiotic strains were also associated with improvements in glucose tolerance, total and LDL cholesterol levels, and leptin levels.

“The anti-obesity activity of the combination has been shown to modulate lipid metabolism and fat accumulation by upregulation of phosphorylation of the AMPK / ACC signaling pathway in liver and adipose tissue ”, the researchers explained. “AMPK plays a critical role in lipid homeostasis as a regulator of fat production and fatty acid oxidation in adipose tissue, liver, and skeletal muscle through the modulation of fat factors. transcription”,they added.

Translation to humans?

Translating the potential benefits to humans is clearly the next step. Earlier this year, scientists at APC Microbiome Ireland reported that the anti-obesity effects of Bifidobacterium longum APC1472, which had previously been reported in laboratory animals, were only partially reflected in overweight / obese adults.

Write in EBioMedicine, Dr Harriët Schellekens and colleagues reported that mouse data indicated that supplementing a high-fat diet with B. longum APC1472 resulted in decreased body weight, less fat accumulation, and tolerance to fat. increased glucose, compared to control animals. However, when performed in humans, there was no significant impact associated with APC1472 on body mass index (BMI) or waist-to-hip ratio (W / H). Cork-based scientists found that the probiotic improved blood sugar levels and helped normalize active ghrelin levels and arousal cortisol response in overweight / obese adults.

Source: Beneficial microbes
Published online ahead of print, doi: 10.3920 / BM200.0205
“Combination ofLimosilactobacillus fermentum MG4231 and MG4244 reduce lipid accumulation in obese mice fed a high fat diet “
Authors: SJ Kim et al.

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