Scientists discover probiotic candidate from Peruvian fermented drinks


Lactiplantibacillus plantarum *Ch13 has been shown to survive the harsh conditions of the intestinal tract and has shown better ability to adhere to the intestinal epithelium than the commercial probiotic strain Lake. plantar299v (DSM9843).

“It is a candidate for further study in order to characterize its potential health benefits”, wrote the scientists in Probiotics and antimicrobial proteins.

* Lactiplantibacillus plantarumwas formerly known as Lactobacillus plantarum. For more information on taxonomic changes in the genus Lactobacilli,please click HERE.

Traditional fermented foods and drinks

The researchers focused on ‘Masato de Yuca’, an Amazonian drink made from cassava (Manihot esculenta) And “Chicha de Siete Semillas”, which is composed of different flours of cereals, pseudo-cereals and legumes.

“These artisanal foods are a natural source for the isolation of new microorganisms, because they are obtained by spontaneous and uncontrolled fermentation, thus preserving the biodiversity of the natural microbiota; then, they constitute a precious source of microbial diversity, ready to be explored ”, they explained.

“However, despite the strong potential of these heritage fermented foods, studies on their microbiota and their genetic diversity are rare or even non-existent in some cases. “

Study details

After obtaining permission from local authorities according to the Nagoya protocol, the researchers isolated lactic acid bacteria from the two fermented drinks. Out of 33 initial isolates, the researchers obtained 16 strains. They noted that at Chicha all the strains isolated were Lake. plantar, while in Masato the strains consisted of Lake. plantar, Limosilactobacillus fermentum(formerly Lactobacillus fermentum), Pediococcus acidilactici, and Weissella confuses.

Tolerance to the human digestive tract was assessed using INFOGEST in vitrodigestion model, the results showing that Lake. plantarCh13 is robust and able to survive the harsh conditions of the gastrointestinal tract better than other strains.

In addition, Ch13 also showed strong adhesion to the human intestinal epithelial cell line HT29.

“Ten of these strains showed mean percentages of adhesion equal to or greater than the probiotic strain 299v (1.49%); remarkably, the strains Lake. plantar Ch13 (6.24%) and Lim. close M31 (5.31%) exhibited a notable ability to adhere to colonocytes, which is one of the selection criteria for candidates to better characterize their probiotic health benefits, ie the probiotic potential ” , write the researchers.

While the adhesion results were promising for Lim. closeM31, this strain did not survive well in INFOGEST testing, leading researchers to claim “Alternative solutions … to improve performance after oral administration”.

Source: Probiotics and antimicrobial proteins
Published online ahead of print, doi: 10.1007 / s12602-021-09836-x
“Masato de Yuca” and “Chicha de Siete Semillas”, two traditional fermented vegetable drinks from Peru as a source for the isolation of potential probiotic bacteria
Authors: TD Rebaza-Cardenas, et al


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